How does long-term use of NSAIDs affect the stomach?
Anti-inflammatory pain relievers like ibuprofen work by temporarily blocking the production of pain-causing chemicals called prostaglandins. At the site of pain, prostaglandins activate nearby nerve endings, which tell the brain the location and severity of the pain.
Prostaglandins also help to protect the stomach lining. In some people, blocking prostaglandins long-term can interrupt this protective mechanism and allow stomach ulcers to form.
When you take Nurofen as directed on the pack (short-term and at low doses), the production of prostaglandins is suppressed temporarily and there is very little chance that you will experience any stomach problems.
See a doctor or pharmacist for further advice if you need long-term pain relief.
The Royal Children’s Hospital Melbourne. Pain relief for children – paracetamol and ibuprofen. Available at: www.rch.org.au/kidsinfo/fact_sheets/Pain_relief_for_children_-_Paracetamol_and_Ibuprofen/ Accessed 04 September 2014.
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3.Autret-Leca et al. Curr Med Res Opin 2007; 23(9): 2205–11, funded by Reckitt Benckiser.
Colmar Brunton OMNI Research, June 2014.
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